:         Educational Web Site on Brain Tumors with Full Text Journal Links : Educational Web Site on Brain Tumors with Full Text Journal Links

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Glioma,Brain Tumor,PET,FDG,Glioblastoma


Neuroscience Research Focus : Primary Brain Tumors
Genetic Disorders can raise the tisk for glioma: Neurofibromatosis type 1 or 2, von Hippel-Lindau disease, Tuberous sclerosis, Li-Fraumeni syndrome, Turcot syndrome type 1 and type 2, Klinefelter syndrome, and Nevoid basal cell carcinoma syndrome
-TBTS - - ABTA - - Trials - - NBTF - - Peds. - - Child - - PBT -

Primary Brain Tumor Pathologies:

Pilocytic astro.(grade I)
Diffuse astro.(grade II
Anaplastic astro.(grade III)
Glioblastoma (grade IV)
Oligodendroglioma(grade II)
Anaplastic oligo.(grade III)
Oligoastrocytoma (grade II)
Anaplastic oligoastro.(grade III)

GBM is the most aggressive tumor sub-type

Related Neuro-Oncology Topics

germ cell tumor
Pleomorphic xanthoastrocytoma
Subependymal giant cell astrocytoma
About half of metastatic brain and spinal cord tumors are caused by lung cancer.

The exact cause of most primary adult brain tumors remains unknown: .

Although the above listed genetic syndromes raise the risk, there other factors that are known as well in certian cases: Being exposed to vinyl chloride may increase the risk of glioma; Past treatment with radiation therapy to the scalp or brain may increase the risk of meningioma; Infection with the Epstein-Barr virus, having AIDS (acquired immunodeficiency syndrome), or receiving an organ transplant may increase the risk of primary CNS lymphoma..

Other unusual tumors include: Cerebellar liponeurocytoma, Paraganglioma, Ependymoblastoma, Supratentorial primitive neuroectodermal tumor (PNET), Choroid plexus papilloma or carcinoma, and Pineal parenchymal tumors
Unusual tumors also include : Astroblastoma, Chordoid glioma of the third ventricle, Gliomatosis cerebri, Gangliocytoma or ganglioglioma, Desmoplastic infantile astrocytoma or ganglioglioma, Dysembryoplastic neuroepithelial tumor, and Central neurocytoma
RESEARCH can cure Glioma

The types of cancer that commonly spread to the brain are melanoma and cancer of the breast, colon, lung, and unknown primary site. The types of cancer that commonly spread to the spinal cord are lymphoma and cancer of the lung, and breast. About half of metastatic brain and spinal cord tumors are caused by lung cancer. Leukemia, lymphoma, breast cancer, and gastrointestinal cancer may spread to the leptomeninges

Learn more about Glioma through links to free full text articles Alternate Web Site Link

Glioblastoma Information Links
International Brain Tumour Alliance (IBTA)
Brain Tumor Organization TBTS
Brain Tumor Organization ABTA
Brain Tumor Clinical Trials
Children with Brain Tumors
BT Organization for Children
Pediatric BT Foundation
SouthEastern BT Foundation
Learn more about other Neurologic Diseases through links to free full text articles

ALS Video Link (film by Dr. L. Kurland on Guamanian ALS) ALS in Guam



PET Imaging of Glioblastoma:

Web Site Link to Learn About PET

Web Site Link to Proton Therapy & PET Review Proton Tx & PET

Proton Beam Therapy for Malignant Neoplasms : Potential for development of research applications in the treatment of Glioblastoma
Although proton beam therapy protocols for brain tumor treatment are not typically used at the major treatment facility sites, there is great potential to explore this further for glioblastoma treatment ( a 1999 study concluded that "...The median survival time was extended to 20 months, likely as a result of central control.." ) Click here for Fitzek, Journal of Neurosurgery, August 1999:
Web Site Link to Learn About Proton Beam Therapy Loma Linda University Medical Center

Neutron Capture Therapy for Glioma : Alternative approaches developed by Dr. Mike Meyer that do not depend on a reactor and boron based tumor avid agents Click here for book chapter by Dr. Mike Meyer and colleagues in : Frontiers in Neutron Capture Therapy
Electron Microscopy of Glioblastoma:

Glioblastoma Pathology:

Standard Treatments for Glioblastoma:

Mechanism of Action for Temodar in Glioblastoma Treatment:

The Normal Astrocyte:

Malignant Transformation into Glioblastoma:

Experimental Radiotherapy of Glioblastoma:

Positron Radiotherapy Article by Dr. Meyer with related references: 18F-FDG Radiotherapy

Positron Radiotherapy for Cancer:

Development of new Cancer imaging methods and therapies:

Free links to full text journal articles:
November 2006 through 2007 - Selected articles:
Gliadel wafers in the treatment of malignant glioma: a systematic review
Regulation and function of aquaporin-1 in glioma cells
central regulator of glioma invasion
intensity modulated radiation therapy
recommendations for the treatment of GBM
DNA methyltransferase
vascular endothelial growth factor
Necrosis induction
A novel small molecule that selectively inhibits GBM
IGF2 signaling
prognostic marker for survival
Notch signaling enhances nestin expression in gliomas
HEDGEHOG-GLI1 signaling
Epidermal growth factor receptor activation
chemoresistance of CD133+ cancer stem cells in glioblastoma
HIV protease inhibitors and GBM

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Long Term Survival after GBM Diagnosis:
Long Term Survival is a well described phenomenon - click below to find out more details:

Six cases of GBM with LTS with an average survival of 9 years (range 5-15 years) were identified
intermediate fibrillary elements were more common in LTS
MIB-1 and topoisomerase II alpha LIs were related significantly to survival
Loss of 19q may be a marker of long-term survival
LTS were more likely to have p53-overexpressing tumors
A patient's plea--breaking the news
interferon-beta and radiation: case report

The link between the JC Virus and Glioma:
Fatal Astrocytoma Autopsy Diagnsois at a major European University Hospital later re-classified as PML
argues against the association of JC and BT
T-antigen expression was detected in the nuclei of tumor cells
The JCV early gene product, T antigen, in medulloblastoma
JCV and medulloblastoma
primitive tumors originating from the cerebellum
immunocompetent patient with an oligoastrocytoma
medulloblastoma induction by JC viral strain Tokyo-1
JCV-induced owl monkey glioblastoma
neurooncogenicity of strains of JC virus

New Advances in Glioma Research:
CD133 cells from human GBM may be novel targets for therapeutics
high-capacity helper-dependent adenoviral vectors
Targets for GBM Tx
cytotoxic and immune mediated gene-based therapies
treatment with hsFlt3L leads to inhibition of tumor growth
laminin-8 may facilitate tumor invasion and tumor regrowth after therapy

For more information, please contact : Dr. Mike Meyer,University at Buffalo Professor of Clinical Neurology and Nuclear Medicine, Erie County Medical Center Chief of Neurology and Stroke Services, Attending Neurologist for SUNY Dept Neurology and Jacobs Neurological Institute, SUNY Buffalo (Contact information: ECMC Dept. Neurology, 462 Grider Street, Buffalo, NY tel 716-898-3638)
Dr. Meyer and JNI Dr. Meyer and JNI
Dr. Meyer's CV Summary Page Dr. Meyer CV Summary Page
PET Scan Web Site Link
Development of FDG as a Cancer Diagnostic Tracer